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. Author manuscript; available in PMC: 2017 Jan 1.
Published in final edited form as: Mutat Res Rev Mutat Res. 2015 Dec 2;767:77–91. doi: 10.1016/j.mrrev.2015.11.001

Figure 6. No detected changes in DNA damage or responses after repeated exposure to low level radiation.

Figure 6

After continuous exposure over 5 weeks to 0.0002 cGy/min radiation (400-fold over background radiation), the exposed mice did not demonstrate increased levels of DNA nucleobase damage (hypoxanthine, 8oxoG, 1,N6-ethenoadenine, or 3,N4-ethenocytosine) or DNA fragmentation (MNT assay and double strand break–induced HR) above background levels. In addition, low dose-rate radiation did not induce Cdkn1a, Gadd45a, Mdm2, Atm, or Dbd2 gene expression before and after irradiation (from Olipitz et al. [93]). The same total dose delivered acutely induced both MN and transcriptional responses.