Table 2.
Characteristics of patients with a diagnosis of retinoblastoma (Rb) (n = 140)
| N | % | |
|---|---|---|
| First sign or symptoma | ||
| Leukocoria | 103 | 73.6 |
| Strabismus | 29 | 20.7 |
| Glaucoma | 4 | 2.9 |
| Buphthalmos | 4 | 2.9 |
| Proptosis | 4 | 2.9 |
| Hyperemia | 4 | 2.9 |
| Ocular pain | 3 | 2.1 |
| Anisocoria | 3 | 2.1 |
| Blindness | 2 | 1.4 |
| Orbital edema | 2 | 1.4 |
| Hyphema | 2 | 1.4 |
| Visual deficiency | 1 | 0.7 |
| Cervical adenopathy | 1 | 0.7 |
| Ecchymosis | 1 | 0.7 |
| Total eyes involved | 187 | 66.8 |
| Ocular laterality | ||
| Unilateral Rb | 91 | 65.0 |
| Right eye | 50 | 54.9 |
| Left eye | 41 | 45.1 |
| Bilateral Rb | 46 | 32.9 |
| Trilateral Rb | 3 | 2.1 |
| Systemic dissemination at diagnosis | ||
| Non-metastatic disease | 125 | 89.3 |
| Metastatic disease | 15 | 10.7 |
| Metastatic sites at diagnosis | ||
| Orbit | 12 | 80.0 |
| CNS | 8 | 53.3 |
| Bone | 4 | 26.7 |
| Bone marrow | 3 | 20.0 |
| Cerebrospinal fluid | 2 | 13.3 |
| Cervical lymph nodes | 1 | 6.7 |
Legend: Ages, time to diagnosis and duration of follow-up are expressed in months; Kruskal-Wallis test was used for analysis of ages and time to diagnosis; Log-rank test was used to estimate duration of follow-up; time to diagnosis: time between onset of the first sign or symptom and diagnosis; duration of follow-up: difference between the patient’s age at diagnosis and their age at the time of the last consultation (if alive) or date of death
CNS central nervous system
asome patients had more than one sign or symptom; more than one site per patient