Table 6.
Follow-up characteristics of patients with Rb according to subgroups
| Laterality (n = 140 patients) | |||||
| Unilateral (n = 91) Age; Age dx (min-max) (months) | Bilateral (n = 46) Age; Age dx (min-max) (months) | Trilateral (n = 3) Age; Age dx (min-max) (months) |
P | ||
| Age at first signs and symptoms | 21.7; 15.0 (0-129.0) | 10.3; 6.0 (0-84.0) | 29.0; 24.0 (3.0-60.0) | [24.0] | <0.001 |
| Age at diagnosis | 13.4; 8.0 (1.0-84.0) | 40.3; 26.0 (15.0-80.0) | <0.001 | ||
| Time to diagnosis | 28.1; 22.0 (1.0-206.0) | 3.1; 2.0 (0-14.0) | 11.3; 12.0 (2.0-20.0) | 0.029 | |
| Duration of follow-up (months) | 6.4; 3.0 (0-77.0) | ||||
| 275.6 (253.2-297.9) | 334.9 (299.3-370.5) | 22.3 (2.9-42.7) | <0.001 | ||
| Laterality for each eye (n = 187 eyes involved) | |||||
| Unilateral (n = 91) Age; Age dx (min-max) (months) | Bilateral (n = 92) Age; Age dx (min-max) (months) | Trilateral (n = 4) Age; Age dx (min-max) (months) | |||
| Time to diagnosis between IO and EO in each subgroup | IO: 4.0; 2.0 (0-20.0) | IO: 2.9; 2.0 (0-14.0) | IO: 2.0; 2.0 (2.0-2.0) | ||
| EO: 10.8; 4.5 (1.0-77.0) | EO: 4.2; 4.0 (0-12.0) | EO: 11.3; 12.0 (2.0-20.0) | |||
| P= 0.003 | P = 0.147 | P = 0.346 | |||
| Duration of follow-up between IO and EO in each subgroup (months) | IO: 293.0 (273.3-312.8) | IO: 355.7 (334.6-376.9) | IO: 4.0 (4.0-4.0) | ||
| EO: 230.9 (180.4-281.4) | EO: 255.5 (174.8-336.3) | EO: 22.3 (2.9-41.7) | |||
| P= 0.002 | P = 0.001 | P = 0.317 | |||
dx diagnosis, CI confidence interval; age, time to diagnosis and duration of follow-up are expressed in months. Kruskal-Wallis test was used for analysis of ages and time to diagnosis; Log-rank test was used to estimate duration of follow-up. Disease extension, IO intraocular, EO extraocular. Time to diagnosis: time between onset of the first sign or symptom and diagnosis (months); duration of follow-up: difference between the patient’s age at diagnosis and their age at the time of the last consultation (if alive) or date of death (months)