Table 7.
Follow-up characteristics of patients with Rb according to subgroups
| Systemic dissemination (n= 140 patients) | |||
| Metastatic (n = 15) Age; Age dx (min-max) (months) | Non-metastatic (n = 125) Age; Age dx (min-max) (months) | P | |
| Age at first signs and symptoms | 32.1; 24.0 (1.0-129.0) | 16.4; 11.0 (0-84.0) | 0.107 |
| Age at diagnosis | 46.5; 26.0 (2.0-206.0) | 20.8; 16.0 (1.0-84.0) | 0.024 |
| Time to diagnosis | 14.3; 4.0 (1.0-77.0) | 4.4; 3.0 (0-26.0) | 0.123 |
| Duration of follow-up (months) | 77.7 (20.6-134.7) | 345.2 (325.6-364.7) | <0.001 |
| Hereditary criteria (n= 140 patients) | |||
| Hereditary (n = 52) Age; Age dx (min-max) (months) | Non-hereditary (n = 88) Age; Age dx (min-max) (months) | P | |
| Age at first signs and symptoms | 12.3; 6.5 (0-84.0) | 21.6; 14.0 (0-129.0) | 0.001 |
| Age at diagnosis | 15.9; 10.5 (1.0-84.0) | 28.0; 21.5 (1.0-206.0) | <0.001 |
| Time to diagnosis | 3.7; 2.0 (0-20.0) | 6.5; 3.0 (0-77.0) | 0.074 |
| Duration of follow-up (months) | 318.2 (280.2-356.2) | 274.0 (250.8-297.2) | 0.844 |
| Disease extension for each eye (n= 187 eyes involved) | |||
| Intraocular (n = 133) Age; Age dx (min-max) (months) | Extraocular (n = 54) Age; Age dx (min-max) (months) | P | |
| Age at first signs and symptoms | 13.6; 8.0 (0-84.0) | 22.7; 12.0 (0-129.0) | 0.001 |
| Age at diagnosis | 16.9; 13.0 (1.0-84.0) | 31.3; 24.0 (1.0-206.0) | <0.001 |
| Time to diagnosis | 3.4; 2.0 (0-20.0) | 8.5; 4.0 (0-77.0) | <0.001 |
| Duration of follow-up | 352.9 (336.0-369.8) | 252.7 (204.7-301.3) | <0.001 |