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. Author manuscript; available in PMC: 2017 Apr 1.
Published in final edited form as: Circ Res. 2016 Apr 1;118(7):1125–1142. doi: 10.1161/CIRCRESAHA.116.308391

Figure 5. GDF11/MSTN in humans.

Figure 5

A) Incidence of heart failure hospitalization, stroke, myocardial infarction, all-cause death, and their composite end-point in the HUNT3 cohort, unadjusted, stratified by quartile of GDF11+MSTN. Quartile 1 is the referent quartile with the lowest GDF11+8 concentrations. P-values for trend are <0.001 for heart failure, death, and composite end-point, 0.004 for stroke, and 0.02 for myocardial infarction. B) GDF11+MSTN levels by age in HUNT3 cohort, unadjusted. Inner line = median, box 25th-75th percentile, outer whiskers denote adjacent value 1.5 times height of box. Units = relative fluorescence units. P-value is < 0.001. This figure is reproduced from Olson et al.143 with permission from the European Heart Journal.