Table 3.
Numbers of targets and therapeutic approaches for each hallmark with the following relationships: complementary relationship, contrary relationship, no known relationship and controversial relationship. Based on cross-validation tables.
| Type of relationship |
Genomic Instability |
Sustained Proliferative Signaling |
Tumor- promoting Inflammation |
Evasion of Anti- growth Signaling |
Resistance to Apoptosis |
Replicative Immortality |
Deregulated Metabolism |
Immune System Evasion |
Angiogenesis | Tissue Invasion and Metastasis |
Tumor Microenvironment |
|---|---|---|---|---|---|---|---|---|---|---|---|
| Targets | |||||||||||
| Complementary | 30 | 52 | 53 | 53 | 62 | 34 | 55 | 44 | 44 | 65 | 61 |
| Contrary | 2 | 1 | 6 | 0 | 1 | 0 | 0 | 2 | 9 | 5 | 3 |
| None known | 52 | 24 | 18 | 20 | 13 | 37 | 23 | 34 | 15 | 7 | 9 |
| Controversial | 1 | 5 | 6 | 7 | 4 | 12 | 5 | 4 | 12 | 3 | 7 |
| Therapeutic Approaches | |||||||||||
| Complementary | 35 | 51 | 44 | 50 | 62 | 37 | 42 | 22 | 40 | 60 | 64 |
| Contrary | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 3 | 2 | 1 | 0 |
| None known | 39 | 20 | 26 | 17 | 11 | 37 | 27 | 39 | 23 | 11 | 9 |
| Controversial | 1 | 8 | 5 | 5 | 1 | 1 | 6 | 12 | 7 | 0 | 0 |