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SR2067 induces a global fold similar to that by other PPARγ partial agonists. Several crystal structures of the PPARγ LBD were superimposed (Cα shown as wires). The rosiglitazone structure is shown in yellow (PDB: 4EMA), the INT131 bound structure is shown in green (PDB: 3FUR), the SR2067 structure is shown in red (PDB: 4R06), and the MRL24 bound structure is shown in cyan (PDB: 2Q5P).
