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AF2 binding pocket. The PPARγ LBD is shown as ribbons (yellow for the rosiglitazone bound structure, and red for the SR2067 bound structure) and rosiglitazone (carbon atoms are colored yellow) and SR2067 (carbon atoms are colored blue) are depicted as sticks. (A) Rosiglitazone hydrogen-bond network in the AF2 pocket. (B) SR2067 hydrogen-bond network in the AF2 pocket. (C) Superimposition of the rosiglitazone and SR2067 structures in the AF2 region.
