Table 1.
Scn1a+/− (Last exon deletion) | F1.Scn1a+/− (First exon deletion) | 129.Scn1a+/− (First exon deletion) | |
---|---|---|---|
Genetic background | C57BL/6J | 129S6/SvEvTac:C57BL/6J (50%:50%) | 129S6/SvEvTac |
Spontaneous seizures | Beginning at P21 | Beginning at P18 | None (observed from P24 to P184) |
Premature death | Beginning at P21 | Beginning at P21 | Normal life span |
Sodium current | |||
Inhibitory neurons | P13–14: reduced | P21–24: reduced | P21–24: not affected |
Excitatory neurons | P13–14: not affected | P14–15: not affected | P21–24: increased, but not as large as in F1.Scn1a+/− |
P21–24: significantly increased | |||
Excitability | |||
Inhibitory neurons | P13–14: reduced evoked firing | ||
Excitatory neurons | P21–24: increased spontaneous action potential firing and evoked firing in both strains; greater increases in F1.Scn1a+/− than in 129.Scn1a+/− | ||
References | Yu et al. 2006 | Miller and Sotero de Menezes 2014; Mistry et al. 2014 |
P, postnatal day.