Table 1.

Effects of Scn1a deletion in mouse models of Dravet syndrome

	Scn1a+/− (Last exon deletion)	F1.Scn1a+/− (First exon deletion)	129.Scn1a+/− (First exon deletion)
Genetic background	C57BL/6J	129S6/SvEvTac:C57BL/6J (50%:50%)	129S6/SvEvTac
Spontaneous seizures	Beginning at P21	Beginning at P18	None (observed from P24 to P184)
Premature death	Beginning at P21	Beginning at P21	Normal life span
Sodium current
Inhibitory neurons	P13–14: reduced	P21–24: reduced	P21–24: not affected
Excitatory neurons	P13–14: not affected	P14–15: not affected	P21–24: increased, but not as large as in F1.Scn1a+/−
		P21–24: significantly increased
Excitability
Inhibitory neurons	P13–14: reduced evoked firing
Excitatory neurons		P21–24: increased spontaneous action potential firing and evoked firing in both strains; greater increases in F1.Scn1a+/− than in 129.Scn1a+/−
References	Yu et al. 2006	Miller and Sotero de Menezes 2014; Mistry et al. 2014

P, postnatal day.