Table 2.
Summary of trimester-specific RIs for TSH and FT4.
| Assays and references | Country | Enrolled number | Excluded TPOAb, TgAb | Percentile used | Reference interval | |||
|---|---|---|---|---|---|---|---|---|
| First trimester | Second trimester | Third trimester | ||||||
| Immulite 2000 | ||||||||
| Lambert-Messerlian et al., 2008 [9] | USA | 9,562 | Yes | 5–95 | TSH | 0.12–2.68 | 0.35–2.77 | |
| Karakosta et al., 2011 [11] | Greece | 425 | Yes | 2.5–97.5 | TSH FT4 |
0.05–2.53 12.36–20.59 |
0.18–2.73 10.81–18.53 |
|
| Present study | China | 3314 | Yes | 2.5–97.5 | TSH FT4 |
0.07–3.96 9.16–18.12 |
0.27–4.53 8.67–16.21 |
0.48–5.40 7.80–13.90 |
| Abbott Architect | ||||||||
| Stricker et al., 2007 [23] | Switzerland | 2,272 | Yes | 2.5–97.5 | TSH FT4 |
0.088–2.829 10.53–18.28 |
0.199–2.792 9.53–15.68 |
0.307–2.903 8.63–13.61 |
| Shen et al., 2014 [17] | China | 1409 | Yes | 2.5–97.5 | TSH FT4 |
0.16–3.78 10.9–17.7 |
0.34–3.51 9.3–15.2 |
0.34–4.32 7.9–14.1 |
| Roche Elecsys | ||||||||
| Marwaha et al., 2008 [24] | India | 541 | Yes | 5–95 | TSH FT4 |
0.6–5.0 12–19.45 |
0.44–5.78 9.48–19.58 |
0.74–5.7 11.3–17.71 |
| Yu et al., 2010 [7] | China | 538 | Yes | 2.5–97.5 | TSH FT4 |
0.02–3.65 11.85–21.51 |
0.36–3.46 9.45–16.26 |
0.44–5.04 9.3–17.14 |
| Moon et al., 2015 [10] | Korea | 769 | Yes | 2.5–97.5 | TSH FT4 |
0.01–4.10 10.68–21.24 |
0.01–4.26 9.13–15.70 |
0.15–4.57 8.37–14.54 |
| Zhang et al., 2015 [8] | China | 3507 | Yes | 2.5–97.5 | TSH FT4 |
0.06–3.13 8.72–15.22 |
0.07–4.13 7.10–13.55 |
0.15–5.02 6.16–12.03 |
| Wang et al., 2011 [5] | China | 1455 | TPOAb | 2.5–97.5 | TSH FT4 |
0.19–3.54 12.01–24.62 |
0.38–3.29 9.53–16.91 |
0.51–5.43 9.37–17.14 |
| Advia Centaur | ||||||||
| Yan et al., 2011 [4] | China | 505 | Yes | 2.5–97.5 | TSH FT4 |
0.03–4.51 11.8–21.0 |
0.05–4.50 10.6–17.6 |
0.47–4.54 9.2–16.7 |
The units of TSH and FT4 in published studies were mIU/L and pmol/L, and the units were converted from the original data when necessary.