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. 2016 Apr 4;6:23837. doi: 10.1038/srep23837

Figure 5. Tyrosine-protein kinase inhibitor genistein suppresses NMDAR currents in human iPSC-derived neurons.

Figure 5

(a) Left, Representative traces show that genistein reversibly inhibited NMDAR currents in a human iPSC-derived neuron. Right, Histogram showing the effect of genistein on NMDAR currents. n = 8, **P = 0.005 using paired t-test. (b) Left, Typical traces showing NMDAR currents elicited at a series of membrane potentials from −60 mV to +60 mV (in 40 mV increments) before (upper) and after (bottom) adding genistein. Right, A plot shows effect of genistein on current-voltage relationship of NMDAR currents in this human iPSC-derived neuron. (c) Left, Averaged mEPSCs recorded at −60 mV before and after adding genistein in a human iPSC-derived neuron. Middle, A graph shows the amplitude of NMDAR-mEPSCs before and after adding genistein in 6 recorded neurons. Right, Histogram showing the effect of genistein on NMDAR-mEPSC amplitude recorded at −60 mV. n = 6, *P = 0.012 using paired t-test.