Table 1. The two-tailed p-values for the Fisher’s exact test show that optimized proteins engaged in critical control are statistically significantly enriched with essential genes for all analysed networks (P < 0.05) except for that of S. pombe, which is not surprising because of the few collected statistics for this organism, as shown in Fig. S9 and Table S1.
| Organism | P-value (Swiss) | P-value (Swiss & TrEMBL) |
|---|---|---|
| C. elegans | 2.51E-01 | 1.55E-02 |
| D. melanogaster | 5.67E-03 | 3.12E-03 |
| H. sapiens 1 | 1.87E-02 | 1.86E-02 |
| H. sapiens 2 | 1.93E-02 | 1.92E-02 |
| H. sapiens OGEE | 1.96E-03 | 1.94E-03 |
| M. musculus | 7.83E-03 | 7.10E-03 |
| S. cerevisiae | 3.01E-07 | 3.01E-07 |
| S. pombe | 8.63E-01 | 8.63E-01 |
| E. coli 1 | 1.41E-04 | 1.41E-04 |
| E. coli 2 | 9.20E-03 | 9.20E-03 |
| E. coli 3 | 4.25E-04 | 4.25E-04 |
The C. elegans results show statistical significance (P < 0.05) for the Swiss & TrEMBL dataset. For E.coli MG1655, we also compiled several datasets. E. coli 1 and 2 refer to data from Gerdes et al.30 and Baba et al.31, respectively. Both datasets were available in the DEG. E. coli 3 refers to the combined data from E. coli 1 and E. coli 2. For H. sapiens datasets see details in methods section.