Table 2. The top-five Gene Ontology (GO) terms for the three GO categories ordered by the number of critical and essential critical genes.
| GO category | Go term | Number of |
Enrichment |
p-Value |
|||
|---|---|---|---|---|---|---|---|
| critical | essential critical | critical | essential critical | critical | essential critical | ||
| Biological Process | transcription, DNA-templated | 67 | 15 | 0.29 | 0.53 | 1.27E-02 | 4.40E-02 |
| Biological Process | gene expression | 52 | 13 | 0.42 | 0.78 | 1.59E-03 | 7.52E-03 |
| Biological Process | positive regulation of transcription from RNA polymerase II promoter | 51 | 21 | 0.59 | 1.45 | 2.71E-05 | 6.78E-09 |
| Biological Process | innate immune response | 43 | 14 | 0.72 | 1.34 | 3.81E-06 | 1.17E-05 |
| Biological Process | viral process | 41 | 9 | 0.58 | 0.81 | 2.06E-04 | 1.76E-02 |
| Cellular Component | cytoplasm | 208 | 45 | 0.35 | 0.56 | 2.62E-10 | 6.19E-06 |
| Cellular Component | nucleus | 198 | 47 | 0.24 | 0.54 | 1.91E-05 | 4.69E-06 |
| Cellular Component | cytosol | 155 | 37 | 0.41 | 0.72 | 7.75E-09 | 1.90E-06 |
| Cellular Component | nucleoplasm | 128 | 36 | 0.26 | 0.74 | 6.77E-04 | 2.28E-06 |
| Cellular Component | plasma membrane | 87 | 20 | 0.24 | 0.52 | 1.14E-02 | 1.60E-02 |
| Molecular Function | ATP binding | 63 | 16 | 0.38 | 0.76 | 1.46E-03 | 2.89E-03 |
| Molecular Function | identical protein binding | 39 | 10 | 0.89 | 1.27 | 1.83E-07 | 4.38E-04 |
| Molecular Function | sequence-specific DNA binding transcription factor activity | 39 | 13 | 0.36 | 1.01 | 1.78E-02 | 7.24E-04 |
| Molecular Function | ubiquitin protein ligase binding | 33 | 9 | 1.26 | 1.70 | 8.77E-11 | 3.27E-05 |
| Molecular Function | ligase activity | 33 | 5 | 0.83 | 0.69 | 5.06E-06 | 1.06E-01 |
The associated enrichment factors and the two-tailed p-values for the Fisher’s exact test are also displayed. The result corresponds to the H. sapiens 1 dataset. For the H. sapiens 2 and H. sapiens OGEE datasets see Supplementary Information.