Table 3. The list of critical genes that are co-expressed in 35 or more human tissues classified according to the KOG functional class for the H. sapiens 1 dataset.
| KOG Functional class | Function | Number of critical genes | Gene name |
|---|---|---|---|
| A | RNA processing and modification | 5 | DDX24, DDX39B, U2AF2, SF3B3, UPF3A |
| B | Chromatin structure and dynamics | 1 | TLE1 |
| C | Energy production and conversion | 1 | ATP6AP1 |
| D | Cell cycle control, cell division, chromosome partitioning | 2 | MOB4, PEA15 |
| E | Amino acid transport and metabolism | 1 | GOT2 |
| F | Nucleotide transport and metabolism | 0 | |
| G | Carbohydrate transport and metabolism | 1 | GAPDH |
| H | Coenzyme transport and metabolism | 1 | ALAS1 |
| I | Lipid transport and metabolism | 1 | FDFT1 |
| J | Translation, ribosomal structure and biogenesis | 4 | EEF1A1, RPLP1, RPL8, RPS3A |
| K | Transcription | 9 | XBP1, CTBP1, MAX, TCF4, ZNHIT3, TCF12, SKP1, MED23, TCEB1 |
| L | Replication, recombination and repair | 1 | XRCC6 |
| M | Cell wall/membrane/envelope biogenesis | 0 | |
| N | Cell motility | 0 | |
| O | Posttranslational modification, protein turnover, chaperones | 14 | UBE2I, UBE2D3, UBE2D2, UBE2D4, RNF11, UBE2E1, UBE2E3, UBE2N, UBE2K, YWHAE, UBE3A, UBE2L6, DNAJA1, CDC34 |
| P | Inorganic ion transport and metabolism | 1 | SAT1 |
| Q | Secondary metabolites biosynthesis, transport and catabolism | 0 | |
| R | General function prediction only | 8 | EWSR1, CDC42, PLEKHF2, RAC1, LMO4, RAP2A, KLF10, PPFIA1 |
| S | Function unknown | 1 | WBP11 |
| T | Signal transduction mechanisms | 13 | NCK1, FYN, CRK, PIK3R1, ACVR1, MAPK14, NUDT3, ARHGDIA, PSEN1, MPP3, PRKAR1A, MAPK10, PPP2CA |
| U | Intracellular trafficking, secretion, and vesicular transport | 1 | SEC23B |
| V | Defense mechanisms | 0 | |
| W | Extracellular structures | 0 | |
| Y | Nuclear structure | 1 | NSFL1C |
| Z | Cytoskeleton | 7 | MAP1LC3B, NDEL1, TUBGCP4, PFN2, GABARAPL2, ARPC3, DYNLL1 |
See SI for the rest of datasets.