Table 1:
Statistical table
| Data structure | Test | Exact p value | N | ||
|---|---|---|---|---|---|
| a | Spine density | Two-factor, btw (treatment) and win (day) | rANOVA | Treatment: p = 6 × 10−7; day: p = 0.40; interaction: p = 0.39 | 28/25 fields of view for 7 sessions for ket vs saline |
| b | Spine formation rate | Two-factor, btw (treatment) and win (day) | rANOVA | Treatment: p = 0.03; day: p = 0.001; interaction: p = 0.03 | 58/97 fields of view for 3 sessions for ket vs saline |
| c | Spine elimination rate | Two-factor, btw (treatment) and win (day) | rANOVA | Treatment: p = 0.9; day: p = 0.003; interaction: p = 0.9 | 58/97 fields of view for 3 sessions for ket vs saline |
| d | Spine formation rate | Two-factor, btw (treatment) and win (day) | rANOVA | Treatment: p = 2 × 10−4; day: p = 0.5; interaction: p = 0.08 | 28/25 fields of view for 7 sessions for ket vs saline |
| e | Spine elimination rate | Two-factor, btw (treatment) and win (day) | rANOVA | Treatment: p = 0.1; day: p = 0.001; interaction: p = 0.07 | 28/25 fields of view for 7 sessions for ket vs saline |
| f | Field of view fraction | Normally distributed | χ2 test | p = 0.005 | 58/97 fields of view for ket vs saline |
| g | Spine density | Two-factor, btw (treatment) and win (day) | rANOVA | Treatment: p = 0.007; day: p = 0.87; interaction: p = 0.98 | 8/8 mice for ket vs saline |
| h | Spine formation rate | Two-factor, btw (treatment) and win (day) | rANOVA | Treatment: p = 0.07; day: p = 0.20; interaction: p = 0.69 | 8/8 mice for ket vs saline |
| i | Spine elimination rate | Two-factor, btw (treatment) and win (day) | rANOVA | Treatment: p = 0.64; day: p = 0.23; interaction: p = 0.62 | 8/8 mice for ket vs saline |
| j | Persistent fraction | Normally distributed | Two-tailed t test | p = 0.3 | 28/25 fields of view for ket vs saline |
| k | Persistent fraction | Normally distributed | Two-tailed paired t test | p = 0.007 | 28 fields of view for ket |
| m | Persistent fraction | Normally distributed | Two-tailed paired t test | p = 0.002 | 28 fields of view for ket |
| n | Persistent fraction | Normally distributed | Two-tailed paired t test | p = 0.1 | 25 fields of view for saline |
| o | Persistent fraction | Normally distributed | Two-tailed paired t test | p = 0.9 | 25 fields of view for saline |
| p | Spine head length | Normally distributed | Two-tailed paired t test | p = 0.02 | 328/328 new vs existing spines |
| q | Spine head width | Normally distributed | Two-tailed paired t test | p = 3 × 10−5 | 328/328 new vs existing spines |
| r | Spine head length | Cumulative fractions | Two-sample Kolmogorov–Smirnov test | p = 9 × 10−6 | 328/328 new vs existing spines |
| s | Spine head width | Cumulative fractions | Two-sample Kolmogorov–Smirnov test | p = 4 × 10−4 | 328/328 new vs existing spines |
| t | Spine head length | Cumulative fractions | Two-sample Kolmogorov–Smirnov test | p = 0.9 | 61/328 spines for pre-ket vs post-ket |
| u | Spine head length | Cumulative fractions | Two-sample Kolmogorov–Smirnov test | p = 0.09 | 61/328 spines for pre-ket vs post-ket |
| v | Spine head width | Cumulative fractions | Two-sample Kolmogorov–Smirnov test | p = 0.2 | 61/328 spines for pre-ket vs post-ket |
| w | Spine head width | Cumulative fractions | Two-sample Kolmogorov–Smirnov test | p = 0.5 | 61/328 spines for pre-ket vs post-ket |
| x | Dendrite length | Two-factor, btw (treatment) and win (day) | rANOVA | Treatment: p = 1 × 10−12; day: p = 0.02; interaction: p = 0.02 | 28/25 fields of view for 7 sessions for ket vs saline |
| y | Dendrite length and formation rate | Two variables: binary (with or without branch loss) and continuous (formation rate) | Regression coefficient | p = 0.2 | 28 fields of view for ket |
| z | Dendrite length and elimination rate | Two variables: binary (with or without branch loss) and continuous (elimination rate) | Regression coefficient | p = 0.3 | 28 fields of view for ket |
| aa | Branch width of imaged dendritic segments | Normally distributed | Two-tailed t test | p = 0.44 | 117 stable and 16 retracted dendritic segments |
| ab | Dendrite length | Two-factor, btw (treatment) and win (day) | rANOVA | Treatment: p = 0.003; day: p = 0.69; interaction: p = 0.69 | 8/8 mice for ket vs saline |
| ac | Change in dendritic spine density | Non-parametric | Wilcoxon ranked-sum | p = 1 | 8/8 mice for ket vs saline |
| ad | Change in dendritic spine density | Non-parametric | Wilcoxon ranked-sum | p = 0.3 | 5 female and 11 male mice |
| ae | Change in dendritic spine density | Two continuous variables | Regression coefficient | p = 0.8 | 16 mice |
| af | Change in dendritic spine density | Two continuous variables | Regression coefficient | p = 0.8 | 16 mice |
| ag | Change in dendritic spine density | Two continuous variables | Regression coefficient | p = 0.16 | 16 mice |
rANOVA, repeated measures ANOVA; btw, between-factor of the ANOVA; win, within-factor of the ANOVA; ket, ketamine administration; saline, saline administration.