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Schematic representation of the experimental design. Phosphate-buffer solution and SKRBT were administered orally at fixed o’clock every day, and testosterone was subcutaneously injected twice every week from the beginning of the test. Each aging male mouse was mated with females at day 30 and was harvested at day 90. PBS: Phosphate-buffer solution; SKRBT: Saikokaryukotsuboreito; T: Testosterone; ITT: Intratesticular testosterone.
