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. Author manuscript; available in PMC: 2017 Mar 18.
Published in final edited form as: Biochem Biophys Res Commun. 2016 Feb 12;471(4):560–565. doi: 10.1016/j.bbrc.2016.02.032

Fig.1. Synthesis and post synthetic modification of polypro peptides.

Fig.1

A. Each peptide repeat unit contained three amino (two Proline-Phenols and one Azido-Proline). After peptide synthesis, GalNAc-PEG-alkyne molecules were attached to Azido-Prolines by a “click chemistry” reaction (highlighted by dashed square). B. MALDI-TOF MS spectrum of PP-15 peptide before (top panel) and after (bottom panel) addition of GalNAc-PEG. C. CD spectra of polypro peptides. The relative proportion of polypro type II helical content can be observed by peak heights at approximately 198 and 218 nM.