Figure 4. Alterations of p75^NTR and sortilin levels in both the cortex and the striatum of zQ175 mice.

(A) At the age of 12 months, p75^NTR level is significantly reduced in the cortex of zQ175 mice, while sortilin level is modestly increased. (B) p75^NTR level is also significantly reduced in the striatum of 12-month-old zQ175 mice, but sortilin level is significantly increased. Both (C) Quantification results of p75^NTR level showing a significant decrease (~40%) of p75^NTR in the cortex and the striatum of both zQ175 heterozygous and homozygous animals. (D) Quantification results of sortilin level showing a modest increase of sortilin in the cortex but a significant sortilin induction in the striatum of both zQ175 heterozygous and homozygous animals.