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. Author manuscript; available in PMC: 2016 Oct 1.
Published in final edited form as: Neurobiol Dis. 2015 Aug 15;82:466–477. doi: 10.1016/j.nbd.2015.08.008

Figure 5. Alteration of p75NTR labeling pattern in the striatum of zQ175 mice.

Figure 5

(A, B) Immunofluorescence staining of p75NTR in the striatum of 12-month-old wild type (A) and zQ175 homozygous mice (B). Note the reduction of p75NTR immunoreactivity of the patch-like labeling but induction of p75NTR in the cell bodies in zQ175/zQ175 striatum. Boxes in (A) and (B) are enlarged in (C) and (D), respectively. Double immunofluorescence staining shows no co-localization between p75NTR (arrowhead) and Darpp-32 (medium spiny neuron marker) in the striatum of both wild type (C) and zQ175 homozygous mice (D). Scale bar: 50μm (A, B), 20μm (C, D).