(A, B) Immunofluorescence staining of p75NTR in the striatum of 12-month-old wild type (A) and zQ175 homozygous mice (B). Note the reduction of p75NTR immunoreactivity of the patch-like labeling but induction of p75NTR in the cell bodies in zQ175/zQ175 striatum. Boxes in (A) and (B) are enlarged in (C) and (D), respectively. Double immunofluorescence staining shows no co-localization between p75NTR (arrowhead) and Darpp-32 (medium spiny neuron marker) in the striatum of both wild type (C) and zQ175 homozygous mice (D). Scale bar: 50μm (A, B), 20μm (C, D).