Table 3.
Selected Genes Associated with NEC Risk Clades 1 and 2
| KOa | pb | Gene Description |
|---|---|---|
| Clade 1 associated | ||
| K10125 | 2.1E-12 | dctB; (C4-dicarboxylate transport) two-component system histidine kinase |
| K10126 | 2.1E-12 | dctD; (C4-dicarboxylate transport) two-component system response regulator |
| K01451 | 2.1E-12 | hipO; hippurate hydrolase |
| K00016 | 2.1E-12 | L-lactate dehydrogenase |
| K02765 | 2.1E-12 | PTS system, Fused glucose-specific IIB component |
| Clade 1 and 2 associated | ||
| K08094 | 7.3E-10 | hxlB; 6-phospho-3-hexuloisomerase |
| K03445 | 7.4E-04 | nepI; MFS transporter, DHA1 family, purine ribonucleoside efflux pump |
| Iron acquisition | ||
| K16087 | 8.2E-05 | chuA: outer membrane heme/hemoglobin/transferrin/lactoferrin receptor protein |
| K07225 | 8.2E-05 | chuS: putative hemin transport protein |
| K07227 | 8.2E-05 | chuX Putative heme iron utilization protein |
| K06202 | 1.6E-03 | CyaY protein |
| K15721 | 1.9E-02 | fyuA; pesticin/yersiniabactin receptor |
| K04786 | 5.2E-03 | irp1; yersiniabactin nonribosomal peptide/polyketide synthase |
| K04784 | 1.9E-02 | irp2; yersiniabactin nonribosomal peptide synthetase |
| K05374 | 1.9E-02 | irp4: ybtT; yersiniabactin synthetase, thioesterase component |
| K04783 | 1.9E-02 | irp5; yersiniabactin salicyl-AMP ligase |
| K04781 | 1.9E-02 | irp9; salicylate synthetase |
| K07230 | 3.0E-04 | putative iron transporter |
| K11607 | 4.5E-04 | sitB; manganese/iron transport system ATP-binding protein |
| K11605 | 4.5E-04 | sitC; manganese/iron transport system permease protein |
| K11606 | 5.1E-05 | sitD; manganese/iron transport system permease protein |
| K05372 | 5.2E-03 | ybtA; AraC family transcriptional regulator |
| Phosphotransferase systems | ||
| K02538 | 1.4E-02 | manR; activator of the mannose operon, transcriptional antiterminator |
| K02768 | 1.4E-02 | PTS system, fructose-specific IIA component |
| K02769 | 1.4E-02 | PTS system, fructose-specific IIB component |
| K02765 | 1.5E-06 | PTS system, Fused glucose-specific IIB component |
| K02812 | 8.2E-05 | sorF; PTS system, sorbose-specific IIA component |
| K02813 | 7.1E-04 | sorB; PTS system, sorbose-specific IIB component |
| K02814 | 7.1E-04 | sorA; PTS system, sorbose-specific IIC component |
| K02815 | 7.1E-04 | sorD; PTS system, sorbose-specific IID component |
| K11189 | 7.1E-04 | fryA; PTS-HPR; phosphocarrier protein |
| Serine | ||
| K01753 | 1.6E-03 | dsdA; D-serine dehydratase |
| K13636 | 1.8E-02 | dsdC; LysR family transcriptional regulator, D-serine deaminase activator |
| K13629 | 3.5E-02 | dsdX; D-serine transporter |
a
KEGG Orthology (KO) identifier
b
p is calculated as two-tailed Fisher’s exact probability. A complete gene list with p values is found in Table S2.