Table 1.

Examples of studies on skeletal stem cell aging and corresponding specific theories of aging

Theory of aging	Target mechanism(s)	References
Free radical damage	Oxidative stress and cell damage	Manolagas (2010), Manolagas and Almeida (2007), Nojiri et al. (2011)
Telomere shortening	Telomeric DNA damage and associated events	Saeed et al. (2011, 2015), Simonsen et al. (2002)
Somatic mutation	DNA repair	Barnhoorn et al. (2014), Chen et al. (2013)
Endocrine control	Endocrine homeostatic mechanisms	Abdallah et al. (2006), Baht et al. (2015), Conboy et al. (2005), Loffredo et al. (2013)