Elderly metastatic colorectal cancer patients received treatment sequences with multiple drugs administered across various lines of treatment.

Oxaliplatin- or irinotecan-based regimens were the most common chemotherapies, bevacizumab was the most common targeted biologic, and the most common treatment sequence was first-line oxaliplatin or irinotecan followed by second-line oxaliplatin or irinotecan + bevacizumab followed by a third-line targeted biologic.

Future research evaluating the comparative effectiveness and cost effectiveness of treatment lines and sequences for elderly patients with metastatic colorectal cancer should be conducted.