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. 2016 Feb 5;19:155–171. doi: 10.1007/s10456-016-9495-8

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© The Author(s) 2016

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made.

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Fig. 6 — In silico analysis of putative KLF6 binding motifs in the MMP14 promoter. a GC-rich domains in the MMP14 promoter fragment −1544/+247. The percentage of GC bases along the promoter is shown. Several GC-boxes that recruit members of the Sp1/KLF transcription factors family were identified. b Putative transcription factor binding motifs for KLF6 (bold letters) in the plus (capitals) and negative (lowercase letters) strands of human MMP14 5′-proximal promoter sequence are indicated. KLF6(+); klf6(−). The translation initiation codon is marked in red. The numbering of the nucleotides is referred to the predicted transcription initiation site (+1) identified by the Genomatix MatInspector software. c Potential KLF6 (red) and Sp1 (blue) binding sites on the MMP14 gene promoter as identified by the Genomatix MatInspector software