Table 1.

Demographic and clinical characteristics of study participants at baseline. Examples of ‘other’ education level include nursing school, film school, and police academy.

	Total cohort	Cases of incident anxiety	Cases of incident depression	Cases of incident alcohol dependence
Variable	n =949	n =138	n=128	n=42
Sex, N (%)
Female	714 (75.2)	99 (71.7)	96 (75.0)	25 (59.5)
Male	235 (24.8)	39 (28.3)	32 (25.0)	17 (40.5)
Race, N (%)
White	810 (94.6)	121 (94.5)	101 (91.0)	33 (97.1)
Non-white	46 (5.4)	7 (5.5)	10 (9.0)	1 (2.9)
Age, mean (SD)	48.6 (11.4)	48.5 (11.2)	48.8 (11.3)	47.0 (11.5)
Age (categorized), N (%)
18–29	58 (6.1)	11 (8.0)	9 (7.0)	4 (9.5)
30–39	149 (15.7)	20 (14.5)	17 (13.3)	7 (16.7)
40–49	305 (32.2)	42 (30.4)	47 (36.7)	13 (31.0)
50+	436 (46.0)	65 (47.1)	55 (43.0)	18 (42.9)
Age of onset, mean (SD)	33.2 (10.0)	33.5 (10.6)	32.2 (9.9)	32.7 (9.0)
Disease duration, mean (SD)	15.4 (10.2)	14.9 (9.9)	16.1 (10.0)	14.3 (8.0)
EDSS, median (IQR)*	2.5 (1.5-5.0)	3.0 (2.0 – 6.0)	3.0 (2.0 – 5.0)	2.5 (1.5 – 4.0)
Clinical course, N (%)
RRMS	687 (72.4)	91 (65.9)	92 (71.9)	34 (81.0)
SPMS	193 (20.3)	37 (26.8)	29 (22.7)	7 (16.7)
PPMS	60 (6.3)	8 (5.8)	7 (5.5)	1 (2.4)
CIS	5 (0.5)	2 (1.5)	0 (0.0)	0 (0.0)
Unknown	4 (0.4)	0 (0.0)	0 (0.0)	0 (0.0)
Current disease modifying therapy use
Yes	477 (50.4)	64 (45.7)	75 (58.6)	21 (50.0)
No	470 (49.6)	76 (54.3)	53 (41.4)	21 (50.0)
Education
High school or less	258 (30.1)	36 (28.1)	36 (32.4)	7 (20.6)
Any post-secondary or more	574 (67.1)	91 (71.1)	72 (64.9)	26 (76.5)
Other	24 (2.8)	1 (0.8)	3 (2.7)	1 (2.9)

EDSS = Expanded Disability Status Scale; IQR = interquartile range; RRMS = relapsing-remitting MS; SPMS = secondary progressive MS; PPMS = primary progressive MS; CIS = clinically isolated syndrome.

^*47 patients from the total cohort were missing an EDSS score at baseline.