Table 2.
Summary of one-year toxicity studies with glyphosate.
| Authors: | Monsanto (1985) |
|---|---|
| Reliability/Justification | 2 Study performed according to GLP and OECD guideline requirements, with the following deviation: MTD not reached by highest dose |
| Substance: | Glyphosate (96.1% pure) |
| Species/Strain: | Dog/Beagle, groups of 6 ♂ and 6 ♀ |
| Administration route: | Oral, capsule |
| Doses: | 0, 20, 100, 500 mg/kg bw/day |
| Duration: | 1 year |
| Findings: | ≥ 500 mg/kg bw/day: NOAEL (♂ + ♀) no treatment-related effects |
| Authors: | Cheminova (1990) |
|---|---|
| Reliability/Justification | 1 Study performed according to GLP and OECD guideline requirements, with no deviations. |
| Substance: | Glyphosate (98.6–99.5% pure) |
| Species/Strain | Dog/Beagle, groups of 4 ♂ and 4 ♀ |
| Administration route: | Oral, capsule |
| Doses: | 0, 30, 300, 1000 mg/kg bw/day |
| Duration: | 1 year |
| Findings: | 300 mg/kg bw/day: NOAEL (♂ + ♀) 1000 mg/kg bw/day: soft, liquid stools (attributable to capsule administration); equivocal impact on body weight gain |
| Authors: | Nufarm (2007) |
|---|---|
| Reliability/Justification | 2 Study performed according to GLP and OECD guideline requirements, with the following deviation: MTD not reached by highest dose |
| Substance: | Glyphosate (95.7% pure) |
| Species/Strain | Dog/Beagle, groups of 4 ♂ and 4 ♀ |
| Administration route: | Oral, capsule |
| Doses: | 0, 30, 125, 500 mg/kg bw/day |
| Duration: | 1 year |
| Findings: | ≥ 500 mg/kg bw/day: NOAEL (♂ + ♀) No treatment-related effects |
| Authors: | Arysta Life Sciences (1997c) |
|---|---|
| Reliability/Justification | 2 Study performed according to GLP and OECD guideline requirements, with the following deviation: MTD not reached by highest dose |
| Substance: | Glyphosate (94.6% pure) |
| Species/Strain | Dog/Beagle, groups of 4 ♂ and 4 ♀ |
| Administration route: | Oral, diet |
| Concentration: | 0, 1600, 8000, 50 000 ppm diet (♂ about 34.1, 182, 1203 mg/kg bw/day; ♀ about 37.1, 184, 1259 mg/kg bw/day) |
| Duration: | 1 year |
| Findings: | 182/184 mg/kg bw/day: NOAEL (♂/♀) At high dose: loose stool, non-statistically significant retarded body weight gain, decreased urinary pH, slight and non-statistically significant focal pneumonia (♀), minor clinical chemistry changes of Cl ↑, albumin ↓, P ↓ (♀) |
| Authors: | Syngenta (1996a) |
|---|---|
| Reliability/Justification | 1 Study performed according to GLP and OECD guideline requirements, with no deviations. |
| Substance: | Glyphosate (95.6% pure) |
| Species/Strain | Dog/Beagle, groups of 4 ♂ and 4 ♀ |
| Administration route: | Oral, diet |
| Concentration: | 0, 3000, 15 000, 30 000 ppm diet (♂ about 90.9, 440, 907 mg/kg bw/day; ♀ about 92.1, 448, 926 mg/kg bw/day) |
| Duration: | 1 year |
| Findings: | 15 000 ppm diet: NOAEL (♀) ≥ 30 000 ppm diet: NOAEL (♂): No treatment-related effects 30 000 ppm diet: slight body weight reduction (♀) |
| Authors: | Syngenta (1996b) |
|---|---|
| Reliability/Justification | 1 Study performed according to GLP and OECD guideline requirements, with no deviations. |
| Substance: | Glyphosate (95.6% pure) |
| Species/Strain | Rat/Wistar Alpk: APfSD, groups of 24 ♂ and 24 ♀ |
| Administration route: | Oral, diet |
| Concentration: | 0, 2000, 8000, 20 000 ppm diet (♂ about 141, 560, 1409 mg/kg bw/day; ♀ about 167, 671, 1664 mg/kg bw/day) |
| Duration: | 1 year |
| Findings: | 8000 ppm diet: NOAEL (♂+♀) 20 000 ppm diet: parotid salivary glands (focal basophilia of the acinar cells considered non-adverse adaptive response, ♂: 13/24, ♀: 15/24), body weight reduction |