Table 4.
Study 1 – Pituitary tumor findings.
| Tumors | Dose group (mg/kg bw/day) | |||||||
|---|---|---|---|---|---|---|---|---|
| Males | Females | |||||||
| 0 | 3.05 | 10.3 | 31.49 | 0 | 3.37 | 11.22 | 34.02 | |
| Pituitary tumors | Number of animals/total number examined (% per group) | |||||||
| Adenomas - B | 16/48 (33) | 19/49 (39) | 20/48 (42) | 18/47 (38) | 34/48 (70) | 29/48 (60) | 31/50 (62) | 26/49 (53) |
| Carcinomas - M | 3/48 (6) | 2/49 (4) | 3/48 (6) | 1/47 (2) | 8/48 (17) | 7/48 (14) | 5/48 (19) | 12/49 (24) |
| Combined | 19/48 (40) | 21/49 (43) | 23/48 (48) | 19/47 (40) | 42/48 (88) | 36/48 (75) | 36/50 (72) | 38/49 (78) |
B benign, M malignant