Table 16.
Study 11 – Two-year feeding study with glyphosate in mice (Cheminova 1993b).
| Study owner: | Cheminova (1993b) | ||||
| Reliability/Justification: | 1 Study performed according to GLP and OECD guideline requirements | ||||
| Substance: | Glyphosate (98.6% pure) | ||||
| Species/Strain: | Mouse/CD-1, groups of 50 ♂ and 50 ♀ | ||||
| Administration route: | Diet | ||||
| Concentration: | ♂+♀: 0, 100, 300, 1000 mg/kg bw/day (regular adjustment of dietary concentration) | ||||
| Duration: | 24 months | ||||
| Findings: | ≥ 1000 mg/kg bw/day: NOAEL (♂+♀) no treatment-related effects |
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| Select neoplasms: | Bronchiolar-alveolar adenoma, bronchiolar-alveolar carcinoma, pituitary adenoma (females) | ||||
| Dose (mg/kg bw/day) | |||||
| Males | 0 | 10 | 300 | 1000 | |
| Bronchiolar-alveolar adenoma – B | 9/50 (18%) | 15/50 (30%) | 11/50 (22%) | 13/50 (26%) | |
| Bronchiolar-alveolar carcinoma – M | 10/50 (20%) | 7/50 (14%) | 8/50 (16%) | 9/50 (18%) | |
| Dose (mg/kg bw/day) | |||||
| Females | 0 | 100 | 300 | 1000 | |
| Bronchiolar-alveolar adenoma – B | 7/50 (14%) | 3/50 (6%) | 3/50 (6%) | 6/50 (12%) | |
| Bronchiolar-alveolar carcinoma – M | 3/50 (6%) | 2/50 (4%) | 1/50 (2%) | 5/50 (10%) | |
| Pituitary adenoma – B | 1/41 (2%) | 0/32 | 0/23 | 3/43 (6%) | |
B benign, M malignant