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. 2015 Mar 20;75(4):687–695. doi: 10.1136/annrheumdis-2014-207191

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This is an Open Access article distributed in accordance with the terms of the Creative Commons Attribution (CC BY 4.0) license, which permits others to distribute, remix, adapt and build upon this work, for commercial use, provided the original work is properly cited. See: http://creativecommons.org/licenses/by/4.0/

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(A) Study A (tofacitinib-naive patients) design evaluating vaccine responses in patients randomised to tofacitinib vs placebo. (B) Study B (patients using tofacitinib) randomisation schemata. Patients were randomised to one of two groups: the ‘continuous’ group, which received tofacitinib without interruption, or the ‘withdrawn’ group, in which tofacitinib was withdrawn for 1 week at randomisation and then resumed 1 week after vaccination. ^aStratified by background methotrexate (MTX) use. BID, twice daily; DMARD, disease-modifying antirheumatic drug; HI, haemagglutination inhibition.