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Effect of TDZD-8 treatment on collagen II induced RA rats. (A1) and (A2) is control group. (B1) and (B2) is collagen II induced RA rats group. (C1) and (C2) is TDZD-8 treatment group, which showed a significant reduction on paw edema. (D) demonstrated the paw volume of three group, which TDZD-8 treatment group significantly decrease the paw volume of collagen II induced RA in rats.
