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. 2016 Feb 23;590(5):605–612. doi: 10.1002/1873-3468.12089

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© 2016 The Authors. FEBS Letters published by John Wiley & Sons Ltd on behalf of Federation of European Biochemical Societies.

This is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.

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Amino acid sequence alignment of the NPC1DC β2–β3 and β7–β8 hairpin regions. Alignment of NPC1 DC β2–β3 and β7–β8 hairpin regions from Human (Homo sapiens), Monkey (Rhesus macaque), Dog (Canis lupus familiaris), Bat_Eh (Ediolon helumn), Bat_Ra (Rousettus aegyptiacus), Pig (Sus scrofa), Mouse (Mus musculus) and Chicken (Gallus gallus). Names of susceptible species are coloured in red, and refractory species in green. Numbering corresponds to the full length human NPC1, conserved residues are shown in a red background. Secondary structure elements are labelled on the top. The positions of H418, Q421, D502 and F504 are marked green to indicate the difference in susceptibility to Filovirus infection.