Table 1.
BDNF protein in serum, hippocampus and amygdala homogenates and BDNF and TrkB receptor mRNA levels in hippocampal homogenates (± SEM)
Parameter | Control rats | BDNF+/− rats |
---|---|---|
Serum BDNF protein (ng/ml) | 1.1 ± 0.1 | 0.3 ± 0.04*** |
Hippocampal BDNF protein (ng/g ww) | 3.6 ± 0.1 | 2.5 ± 0.2*** |
Amygdala BDNF protein (ng/g ww) | 2.9 ± 0.3 | 1.6 ± 0.4* |
Hippocampal BDNF mRNA (AU) | 0.9 ± 0.1 | 0.9 ± 0.1 |
Hippocampal TrkB mRNA (AU) | 1.1 ± 0.1 | 1.3 ± 0.1 |
AU, arbitrary units.
P < 0.05 unpaired t‐test;
P < 0.001.