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. 2015 Dec 1;43:974–982. doi: 10.1007/s00259-015-3260-x

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© The Author(s) 2015

Open Access This article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made.

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Fig. 5 — a c Ex vivo immunohistochemical staining for HSP90, EGFR and CD44v6 expression on representative sections of a A431 and c UM-SCC-74B tumour xenografts (×10). A431 tumours show high expression and UM-SCC-74B tumours show low expression of EGFR and CD44v6. HSP90 and EGFR were downregulated in the AT13387 treatment group. CD44v6 expression was unchanged. b, d Semiquantitative analysis of immunostaining using the H-score (n = 16, error bars SD; ****p < 0.0001, one-way ANOVA with Tukey’s post hoc test)