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Biomarker index.
| On-treatment biomarkers a | Observation | Points | |
|---|---|---|---|
| Sodium | ≥LLN | 1 | |
| <LLN | 0 | ||
| LDH | ≤1.5 times ULN | 1 | |
| >1.5 times ULN | 0 | ||
| Platelets | <LLN | 1 | |
| ≥LLN | 0 | ||
| Neutrophils | <LLN | 1 | |
| ≥LLN | 0 | ||
| Systolic blood pressure | ≥140 mmHg | 1 | |
| <140 mmHg | 0 |
aMeasured after treatment start and within 12 weeks of treatment. LDH, lactate dehydrogenase; LLN, lower level of normal; ULN, upper level of normal.
Good biomarker profile: 3–5 points.
Poor biomarker profile: 0–2 points.
