Figure 3.

Drug-host factor interaction network. This network contains 78 host factors that interact with 177 FDA-approved drugs, which were retrieved from the DrugBank database. These drugs can be repositioned for the treatment of RSV infection. Host factors are indicated by open circles with red color border representing upregulated and blue color border representing downregulated level of expression. FDA-approved small molecule drugs are represented by arrowheads and biotech drugs are represented by octagons. Fill colors of drugs represent the Anatomical Therapeutic Chemical (ATC) classification: Metabolism (cyan); Blood (red); Cardiovascular (pink); Dermatologicals (blue); Genito-urinary (light blue); Anti-infectives (green); Anti-neoplastics (orange); Musculo-skeletal (light purple); Nervous system (salmon pink); Anti-parasitic (yellow); Respiratory system (light green); Sensory organs (blue-green); and Various systems (white).