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Linear plot of baseline-corrected mean plasma concentration versus time for (a) estradiol (n = 36), (b) estrone (n = 36), and (c) estrone sulfate (n = 36) after treatment with the test and reference preparations, each at 25 μg. Test product: TX-004HR; TherapeuticsMD, Inc., Boca Raton, FL. Reference product: Vagifem®; Novo Nordisk, Plainsboro, NJ.
