Table 3.
Baseline Demographic and Disease Characteristics According to Age: Safety Population
| Characteristic | <75 | ≥75 | ||||
|---|---|---|---|---|---|---|
| Non‐canagliflozin, n = 3,107 | Canagliflozin 100 mg, n = 2,929 | Canagliflozin 300 mg, n = 2,913 | Non‐canagliflozin, n = 155 | Canagliflozin 100 mg, n = 163 | Canagliflozin 300 mg, n = 172 | |
| Sex, n (%) | ||||||
| Male | 1,828 (59) | 1,700 (58) | 1,649 (57) | 96 (62) | 103 (63) | 117 (68) |
| Female | 1,279 (41) | 1,229 (42) | 1,264 (43) | 59 (38) | 60 (37) | 55 (32) |
| Age, mean ± SD | 58.8 ± 8.5 | 59.0 ± 8.7 | 58.9 ± 8.6 | 77.6 ± 2.8 | 77.5 ± 2.2 | 77.4 ± 2.9 |
| Race, n (%) | ||||||
| White | 2,239 (72) | 2,095 (72) | 2,090 (72) | 143 (92) | 144 (88) | 146 (85) |
| Black | 114 (4) | 112 (4) | 124 (4) | 4 (3) | 3 (2) | 2 (1) |
| Asian | 501 (16) | 494 (17) | 480 (16) | 5 (3) | 2 (1) | 11 (6) |
| Othera | 253 (8) | 228 (8) | 219 (8) | 3 (2) | 14 (9) | 13 (8) |
| Glycosylated hemoglobin, %, mean ± SD | 8.0 ± 0.9 | 8.1 ± 0.9 | 8.0 ± 0.9 | 7.9 ± 0.9 | 7.9 ± 0.8 | 7.8 ± 0.8 |
| Fasting plasma glucose, mg/dL, mean ± SD | 166.2 ± 42.8 | 167.7 ± 42.9 | 166.0 ± 44.1 | 164.0 ± 43.7 | 158.7 ± 39.5 | 160.0 ± 43.7 |
| Estimated glomerular filtration rate, mL/min per 1.73 m2, mean ± SD | 82.0 ± 20.4 | 82.6 ± 20.0 | 82.2 ± 20.6 | 62.5 ± 17.3 | 62.7 ± 17.7 | 63.8 ± 18.5 |
| Body mass index, kg/m2, mean ± SD | 32.0 ± 6.1 | 32.0 ± 6.1 | 32.0 ± 6.1 | 30.2 ± 5.1 | 29.7 ± 4.4 | 30.0 ± 4.7 |
| Duration of type 2 diabetes mellitus, years, mean ± SD | 10.0 ± 7.2 | 10.4 ± 7.4 | 10.4 ± 7.4 | 16.8 ± 9.2 | 16.0 ± 8.6 | 16.3 ± 8.7 |
| Background use of diuretics, n (%) | ||||||
| Any | 1,095 (35) | 994 (34) | 989 (34) | 74 (48) | 82 (50) | 87 (51) |
| Loop | 227 (7) | 189 (7) | 215 (7) | 29 (19) | 27 (17) | 35 (20) |
| Nonloop | 949 (31) | 869 (30) | 858 (30) | 53 (34) | 63 (39) | 64 (37) |
Percentages may not total 100% because of rounding.
a
American Indian or Alaska Native, Native Hawaiian or other Pacific Islander, multiple, not reported, other, unknown.
SD = standard deviation.