Table 1.

Demographic and test metric comparison between clinical cohorts

Variable	CLIA laboratory n = 86 658a	Futch et al.10 n = 6123b
Maternal age (years)
n	85 200	6123
Mean ± SD	35.3 + 5.1	35.0 ± 5.7
Min–max	13.8–57.8c	14.6–51.7
Gestational age (weeks)
n	85 144	6123
Mean ± SD	14.0 ± 4.2	15.6 ± 4.6
Min–max	4d–38	5d–37
Gestational age group, n (%)e
n	85 144	6123
First (10–13.9 weeks)	54 088 (63.5)	2883 (47.2)
Second (14–27.9 weeks)	29 963 (35.2)	3103 (50.8)
Third (28–40+ weeks)	1093 (1.3)	127 (2.1)
Turnaround time (business days)
Mean	3.3	5.1
Interquartile range	2–4	4–6
Total cancelations, n (%)	1376 (1.6)	149 (2.4)
Technicalf	101 (0.1)	43 (0.7)
Administrativeg	1214 (1.4)	106 (1.7)
Site‐specifich	45 (0.05)

CLIA, Clinical Laboratory Improvement Amendments.

^aNot all samples reported all demographic variables; thus, counts are reported separately.

^bData from Futch T., Spinosa J., Bhatt S., De Feo E., Rava R.P., and Sehnert A.J. Initial clinical laboratory experience in noninvasive prenatal testing for fetal aneuploidy from maternal plasma DNA samples. Prenat Diagn 2013; 33:569‐74.

^cMaternal age was confirmed in both low and high extremes; the maternal age range was similar to other large‐scale clinical studies.12, 21

^dSamples received from patients under 10 weeks of gestational age were canceled.

^eTrimester at time of blood draw.

^fTechnical cancelations are samples that did not meet quality control standards; this included high cfDNA (41/101, 58.9%), insufficient cfDNA content (11/101, 7.5%), quality control (QC) failure (43/101, 29.5%), and laboratory processing issue (6/101, 4.1%).

^gAdministrative cancelations did not begin the testing process. Common reasons for administrative cancelations were insufficient sample quantity, tube received beyond stability period (>5 days from draw), test canceled by ordering physician, and gestational age less than 10 weeks.

^hCancelations were because of an international site‐specific sample stability issue that has since been resolved.