. 2016 Mar 29;30(7):1131–1136. doi: 10.1097/QAD.0000000000001034

Table 1.

Distribution of new HIV diagnosis by clinical stage and CD4⁺ cell count at diagnosis and estimated annual rate to clinical AIDS in people with undiagnosed HIV, Italy, 2012.

	Original data								Imputed data^b
CD4⁺ cell count	Asymptomatic		Symptomatic non-AIDS		AIDS		Missing	Total	Asymptomatic		Symptomatic non-AIDS		AIDS		Total	AIDS annual rate (r_i)^a	SE (r_i)^a	p_i^*r_i (from original data)	p_i^*r_i (from imputed data)
	N	% (p_i)	N	%	N	%	N	N	N	% (p_i)	N	%	N	%	N
<20	16	0.893	41	8.577	162	25.352	18	213	22	0.862	51	7.692	214	24.683	287	2.01517	0.41135	0.018	0.017
20–49	36	2.010	47	9.833	171	26.761	5	254	45	1.763	58	8.748	203	23.414	306	0.72072	0.11849	0.014	0.013
50–99	71	3.964	64	13.389	118	18.466	20	253	98	3.840	87	13.122	160	18.454	345	0.43625	0.05728	0.017	0.017
100–149	70	3.908	57	11.925	66	10.329	16	193	105	4.114	79	11.916	94	10.842	278	0.21992	0.03079	0.009	0.009
150–199	104	5.807	44	9.205	45	7.042	13	193	143	5.603	63	9.502	65	7.497	271	0.10771	0.01523	0.006	0.006
200–349	372	20.771	114	23.849	40	6.260	57	526	534	20.925	162	24.434	74	8.535	770	0.03318	0.00282	0.007	0.007
350–499	437	24.400	65	13.598	13	2.034	60	515	599	23.472	93	14.027	26	2.999	718	0.01563	0.0016	0.004	0.004
≥500	685	38.247	46	9.623	24	3.756	102	755	1006	39.420	70	10.558	31	3.576	1107	0.00779	0.00094	0.003	0.003
Total (N)	1791	100	478	100	639	100	291	3199	2552	100	663	100	867	100	4082			∑p_ir_i=0.078	∑p_ir_i=0.076
Missing	9	–	0	–	7	–	867	883	0		0		0		0
Total	1800	–	478	–	646	–	1158	4082	2552		663		867		4082

∑p_ir_i, estimated mean annual progression rate to AIDS for the undiagnosed HIV population; p_i = n_i/N^*100, percentage of patients in CD4⁺ stratum i among newly diagnosed asymptomatic HIV; r_i, annual AIDS rate in CD4⁺ stratum i; SE, standard error.

^aFrom Cascade collaboration (Guiget et al. Open AIDS J. 2008, and Professor K. Porter, personal communication).

^bMean values based on 1000 imputed datasets.