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. Author manuscript; available in PMC: 2016 Apr 4.
Published in final edited form as: Clin Cancer Drugs. 2015;2(2):138–147. doi: 10.2174/2212697X02666150629174704

Table 3.

Cancer-related pathways affected by miR-21, miR-200a and/or miR-141.

KEGG Pathway Pathway ID Number of miRNA Target Genes Within
Pathway
MAPK signaling hsa04010 27
Wnt signaling hsa04310 18
Prostate cancer hsa05215 12
Jak-STAT hsa04630 17
Regulation of actin cytoskeleton hsa04810 17
Chronic myeloid leukemia hsa05220 10
Small cell lung cancer hsa05222 10
Pancreatic cancer hsa05212 9
Regulation of actin cytoskeleton hsa04810 17
Colorectal cancer hsa05210 9
TGF-beta signaling hsa04350 9
Cell cycle hsa04110 10
Melanoma hsa05218 7
Glioma hsa05214 6
Apoptosis hsa04210 7
p53 signaling hsa04115 6

The three miRNAs whose fold change was statistically significant in the qPCR analysis (miR-21, miR-200a and miR-141) were used in the DIANA-mirPath database to identify potential signaling pathways regulated by them. The ones related to carcinogenesis are shown in the list. The number of genes targeted by one or more of the significant miRNAs (miR-21, 200a or miR-141) is annotated in the right column; Number of miRNA target genes within the respective pathway.