Table 4.
Targeted genes regulated simultaneously by miR-21, miR-200a and miR-141 that were up-regulated after exposure of HaCaT cells to arsenic.
| Targeted Genes Regulated by miR-21, miR-200a and miR-141 |
KEGG Pathway | KEGG Pathway ID |
|---|---|---|
| Activin receptor type-2A | ||
| Bone morphogenetic receptor | TGF-beta signaling pathway | hsa04350 |
| Homodomain transcription factor 2 | ||
| T-cell lymphoma invasion and metastasis inducing protein 1, | Regulation of actin cytoskeleton | hsa04810 |
| Phosphatidylinositol-3-phosphate/5-kinase | ||
| Jagged 1 protein | Notch signaling pathway | hsa04330 |
| Activin receptor type-2A | Cytokine-cytokine receptor interaction | hsa04060 |
| Bone morphogenetic receptor | ||
| Phosphatidylinositol-3-phosphate/5-kinase | Inositol phosphate metabolism | hsa00562 |
| Cyclin-dependent kinase 6 | Non-small cell lung cancer | hsa05223 |
| Cyclin-dependent kinase 6 | Glioma | hsa05214 |
| Cyclin-dependent kinase 6 | p53 signaling pathway | hsa04115 |
| Phosphatidylinositol-3-phosphate/5-kinase | Phosphatidylinositol signaling system (PI3K) | hsa04070 |
| Cyclin-dependent kinase 6 | Melanoma | hsa05218 |
| Cyclin-dependent kinase 6 | Pancreatic cancer | hsa05212 |
| Cyclin-dependent kinase 6 | Chronic myeloid leukemia | hsa05220 |
| Cyclin-dependent kinase 6 | Small cell lung cancer | hsa05222 |
| cAMP-responsive element-binding protein 5 | Prostate cancer | hsa05215 |
| Cyclin-dependent kinase 6 | Cell cycle | hsa04110 |
| Thyroid hormone receptor beta | Neuroactive ligand-receptor interaction | hsa04080 |
The genes listed in the left column are common potential targets of miR-21, miR-200a and miR-141. In the center column are annotated some pathways in which those genes are involved.