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. Author manuscript; available in PMC: 2016 Apr 4.
Published in final edited form as: Proteomics. 2016 Jan 28;16(3):448–458. doi: 10.1002/pmic.201500231

Table 1.

Candidate compounds influencing human embryonic stem cell self-renewal and differentiation, based on gene and protein analysis.

Therapeutic agents Reported effect Observed effect Conc tested* Non-toxic conc used
Flurbiprofen Self-renewal Self-renewal 10uM-1mM 50uM
Gatifoxacin Self-renewal Self-renewal 10uM-1mM 5uM
Sinomenine Self-renewal Differentiation 10uM-1mM 50uM
Theanine Self-renewal Differentiation 10uM-1mM 10uM
Digitoxin Differentiation Differentiation 100pM-10nM 5nM
Digoxin Differentiation Differentiation 100pM-10nM 1nM
Cymarin Differentiation Differentiation 10pM-1nM 1nM
Selegiline Differentiation Differentiation 10uM-1mM 100uM
Retinoic Acid** Differentiation Differentiation 100nM-10uM 1uM
*

10uM concentrations used by Desbordes et al., 2008;

**

Positive control for differentiation