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Scope of Alkynes. Conditions: Acetal 2 (0.2 mmol, 1.0 equiv), CuSPh (0.02 mmol, 10 mol %), (R,R)-L3 (0.024 mmol, 12 mol %), alkyne (0.24 mmol, 1.2 equiv), BF3·Et2O (0.4 mmol, 2.0 equiv), MTBD (0.31 mmol, 1.55 equiv), CHCl3 (0.15M), 4 °C, 48 h. Average isolated yield from duplicate experiments (±5%) and average ee from duplicate experiments as determined by HPLC analysis using a chiral stationary phase (±2%), unless otherwise noted. For 26, 28, and 30, result of a single experiment.
