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Transdifferentiation by overexpression of 4F generates functional endothelial cells from human fibroblasts. (a) Transdifferentiation of human fibroblasts into endothelial cells. The diagram represents the time course and the sequential addition of the different media. Representative (b) bright-field and (c) FITC images showing the cobblestone structure of induced endothelial cells at day 7 after transduction of BJ fibroblasts with 4F using an MOI 1 or MOI 5.
