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. Author manuscript; available in PMC: 2016 Nov 24.
Published in final edited form as: ACS Nano. 2015 Oct 12;9(11):10695–10718. doi: 10.1021/acsnano.5b05974

Figure 8.

Figure 8

RXRα activity of retinoid bexarotene in free (Bexarotene), pro-drug (Pro-bexarotene) and pro-drug bubble (PBNB) form at concentrations of 0.5, 5 and 50 μM. A positive control 9-cis retinoic acid was used at positive control at concentration of 5 μM. After addition of luciferase substrate lumeniscence was measured at various time points including (A) 5 min; (B) 10 min; (C) 15 min; (D) 20 min; (E) 25 min; (F) 30 min; (G) 35 min; (H) 40 min; (L) 45 min and (J) 50 min. (K) Change in luciferase activity with time was summarized only to see maximum RXRα agonist efficiency in case of PBNB at 0.5 followed by Pro-bexarotene and bexarotene.