Skip to main content
. Author manuscript; available in PMC: 2016 Nov 24.
Published in final edited form as: ACS Nano. 2015 Oct 12;9(11):10695–10718. doi: 10.1021/acsnano.5b05974

Figure 9.

Figure 9

(a) Schematic of a catheter-Based ultrasound (CBUS) applicators for percutaneous conformal hyperthermia and thermal ablation to targets in soft tissue, (B) Sectored tubular ultrasound transducer showing 360° sector design for creating ablation pattern during the treatment, (C) magnified view of fabricated interstitial CBUS applicator tip showing the two transducers. Each of these transducers can be controlled individually with respect to the needed dose delivery. (D) Table-top TheraVision™ ablation system, which includes image processing and therapy control algorithms. (E) Injection of PBNB under 3D tracked ultrasound image guidance, and (F) the corresponding ultrasound B-mode showing the needle insertion and PBNB injection site. Gross pathology images for the different configurations from ex-vivo experiments (G) Pro-bexarotene-NPs (RD) + US, (H) NB (RD) + US, (I) Pro-bexarotene-NPs (RD) + US ablation, (J) PBNB (RD) + US ablation, (K) PBNB + US ablation, (L) US ablation only. The white arrows in (G), (H), (I) and (J) indicate the presence of rhodamine (RD) around site of injection.