Table 2. Analysis of similarities (ANOSIM) of whole, common, and rare microbiota between disease periods.

	B0	E	T	R	B1
Whole
B0	—	0.210	0.092	0.413	0.562
E	0.012	—	0.276	0.177	0.342
T	0.019	0.012	—	0.778	0.396
R	0.001	0.017	−0.034	—	0.199
B1	−0.007	0.001	0.003	0.014	—
Common
B0	—	0.197	0.01*	0.477	0.533
E	0.011	—	0.04*	0.208	0.488
T	0.145	0.157	—	0.518	0.152
R	−0.005	0.013	−0.008	—	0.140
B1	−0.006	−0.004	0.029	0.022	—
Rare
B0	—	0.123	0.0001*	0.017*	0.574
E	0.027	—	0.0002*	0.024*	0.005*
T	0.195	0.152	—	0.0002*	0.0001*
R	0.194	0.156	0.206	—	0.008*
B1	−0.007	0.149	0.194	0.071	—

ANOSIM test statistic (R) and probability (P) that two compared groups are significantly different at the P<0.05 level (denoted with asterisks) are given in the lower and upper triangles, respectively. ANOSIM R and P values were generated using the Bray–Curtis measure of similarity. Disease states are denoted by (B₀) stable pre-CFPE; (E) CFPE, 30 days prior to CFPE treatment; (T) treatment for clinical exacerbation; (R) 30 days post-CFPE treatment; and (B₁) stable post-CFPE.