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Effect of glutamic-acid on the toxicity and folding of the CLIP6 peptide. (A) Cytotoxicity of CLIP6 (●) and CLIPΔ (○) towards A549 cells after 24 hours of incubation. (B) Circular dichroism spectrum demonstrating that the CLIPΔ (○) peptide displays a β-sheet conformation in the presence of negatively-charged lipid vesicles, while CLIP6 (●) remains unfolded.
