Table 3.

Adverse events

Adverse events	DLBS3233 (n=40)	Placebo (n=40)
	Number of events (number of subjects with event)
Central/peripheral nervous system
Anxiety	3 (2)	0
Appetite exaggerated	9 (7)	10 (7)
Dizziness	16 (10)	10 (7)
Drowsiness	0	1 (1)
Headache	8 (6)	2 (2)
Insomnia	1 (1)	1 (1)
Local coldness	1 (1)	0
Tremor	9 (5)	2 (2)
Vertigo	2 (1)	0
Cardiovascular system
Increased blood pressure	0	3 (3)
Palpitation	11 (6)	4 (4)
Ophthalmologic system
Blurred vision	1 (1)	0
Ear, nose, and throat system
Ear ache	1 (1)	0
Respiratory system
Coughing	0	1 (1)
Dyspnea	1 (1)	0
Laryngitis	1 (1)	0
Pharyngitis	0	1 (1)
Gastrointestinal system
Abdominal pain	0	2 (2)
Appendicitis	1 (1)	0
Constipation	1 (1)	1 (1)
Diarrhea	2 (2)	0
Gastritis	0	1 (1)
Nausea	2 (2)	1 (1)
Reproductive system
Menstrual disorder	3 (2)	0
Urinary system
Polyuria	0	2 (1)
Oliguria	0	1 (1)
Musculoskeletal system
Myalgia	4 (4)	4 (4)
Skin and appendages system
Acne	1 (1)	1 (1)
Dermatitis	0	2 (1)
Pruritus	2 (2)	2 (2)
Hyperpigmentation	0	1 (1)
Body as whole – general
Feeling unwell	1 (1)	0
Fever	1 (1)	3 (3)
General weakness	15 (9)	8 (6)
Influenza-like symptoms	1 (1)	0
Leg pain	2 (2)	1 (1)
Pain	1 (1)	0
Diaphoresis	7 (4)	5 (4)
Total	108 (20)	70 (19)

Note: One subject might have more than one adverse event.