MNPs |
Marine natural products |
FDA |
United States Food and Drug Administration |
EMA |
European Medicines Agency |
OIDD |
The Lilly Open Innovation Drug Discovery Program |
TZD |
Thiazolidinon-2-yl |
THP |
Tetrahydropyran |
JAK |
Janus kinase |
STATs |
Signal transducers and activators of transcription |
VEGF |
Vascular endothelial growth factor |
FLT3 |
Fms-like tyrosine kinase 3 |
RTK |
Receptor tyrosine kinase |
RAS |
Rat sarcoma viral oncogene homolog |
PI3K |
Phosphatidylinositol-4,5-biphopshate 3-kinase |
Ephrin |
Eph receptor interacting protein |
ABL1 |
Abelson murine leukemia viral oncogene homolog 1 |
CML |
Chronic myeloid leukemia |
bFGF |
Basic fibroblast growth factor |
TIE |
Tyrosine kinases with immunoglobulin-like and EGF-like domains |
VEGFRs |
Vascular endothelial growth factor receptors |
Grb2 |
Growth factor receptor-bound protein 2 |
EGF |
Epidermal growth factor |
Ang |
Angiopoietin |
GSK3-β |
Glycogen synthase kinase-3-beta |
PLK |
Polo-like kinase |
SAR |
Structure-activity relationship |
ECFCs |
Endothelial colony-forming cells |
ADSCs |
Human adipose-derived stem cells |
cLogP |
Calculated logarithm of partition coefficient |
HBD |
Hydrogen bond donor |
HBA |
Hydrogen bond acceptor |