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SEM images of cells cultured on patterned substrates. (A) Perpendicularly aligned cell on 70 nm wide ridges on a 400 nm pitch. (B) Detail of previous cell. Filopodia were aligned perpendicularly to the patterns. We also observed filopodia aligned along the patterns. (C) Parallel aligned cell on 1900 nm ridges on a 4000 nm pitch. (D) Filopodia were guided by the topographic pattern.
